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Without a doubt, ERβ expression in the male rat aorta is boosted in the endothelium and smooth muscular tissue cells following vascular injury [Lindner et al., 1998] Furthermore, estrogen signalling hinders TNFα- and oxidized low-density lipoprotein (oxLDL)- induced apoptosis of human endothelial cells in vitro [Spyridopoulos et al., 1997; Florian and Magder, 2008] Furthermore, estrogen-mediated activation of Notch1 secures human umbilical vein endothelial cells from TNFα-induced apoptosis artificial insemination [Fortini et al., 2017] Remarkably, siRNA-knockdown of ERβ, although not ERα, removed the anti-apoptotic result of estrogen [Fortini et al., 2017] Penile erection is the final endpoint of a complex sychronisation in between the main nervous system, peripheral nervous system, endocrine system, voluntary and spontaneous pelvic musculature and the extremely specialized vascular cells of the penis [8-10] Supraspinal centers in the brain integrate sensory input and hormone hints as component of the initiation of libido, arousal and libido.
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Some pathologic procedures can alter degrees of α-MSH and indirectly affect melanogenesis. Α-MSH, like ACTH and thyroid-stimulating hormone, is produced by the former pituitary gland. In Addison's disease (persistent adrenal insufficiency), absence of unfavorable feedback from cortisol generates the anterior pituitary to generate better levels of ACTH. As a spin-off, even more MSH is additionally produced, leading to hyperpigmented lesions in these patients.
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